EN - Anglická CZ - Česká SK - Slovenská PL - Polská RO - Rumunská RU - Ruská TR - Turecká UA - Ukrajinská
EN - Anglická
  • CZ - Česká
  • SK - Slovenská
  • PL - Polská
  • RO - Rumunská
  • RU - Ruská
  • TR - Turecká
  • UA - Ukrajinská

BioBos Respi 4, injection suspension for cattle

Homepage Products Veterinary products BioBos Respi 4, injection suspension for cattle

Vaccine against respiratory diseases in cattle

type of preparative: Vaccines
target species animals: Cattle

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One vaccination dose (2 ml) contains:

Active substances:

Virus respiratoris syncytialis bovis inactivatum, strain BiO-24   RP ³ 1*

Virus parainfluensis 3 bovis inactivatum, strain Bio-23     RP ³ 1* 

Virus diarrhoeae bovis inactivatum., strain BiO-25   RP ³ 1*

Mannheimia (Pasteurella) haemolytica inactivata, strain DSM 5283, serovar 1A   RP ³ 1*

*) Relative efficiency (RP) is given by the comparison of the antibody levels in serum prepared with the reference vaccine batch complying with the challenge test in target animals.                                              

Adjuvants: hydrated aluminium hydroxide for absorption 2%  0.4 ml, quillaja saponin (Quil A)  1%  0.04 ml                                                                           

Excipients: thiomersal 0.01 %, formaldehyde   35% solution 0.05 %

Pinkish liquid with sediment.


For active immunisation of cattle against:

bovine parainfluenza 3 virus, do reduce infection,

bovine respiratory syncytial virus, to reduce infection and clinical symptoms,

bovine viral diarrhoea virus, to reduce infection,

Mannheimia (Pasteurella) haemolytica serotype A1, to reduce clinical symptoms and pulmonary lesions.

Onset of immunity:

Antibody response against BRS virus, PI 3 virus, BVD virus and Mannheimia haemolytica reaches the highest level in 3 weeks after full immunisation programme. Another revaccination is recommended as required within an interval of 6 months after performance of the basic immunisation.

Duration of immunity:

Immunity persists after revaccination for at least 6 months.


Vaccinate only healthy animals. Do not use in animals, that present with signs of the disease.

Adverse reactions:

In relation to the performed vaccination, it is possible to observe development of local swelling, which relates to the content of adjuvant substances in the vaccine. This swelling, which could reach up to 6 cm, usually subsides within 2 – 3 weeks after vaccination. In some cases, there may be temporary mild elevation of body temperature lasting up to 3 days after vaccination. 
If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary surgeon.

Target species:

Cattle from the age of 2 weeks.

Dosage for each species, rote(s) and method of administration:

Vaccine dose – 2 ml, the vaccine is administered subcutaneously. 

Basic immunisation (vaccination with subsequent revaccination):

We recommend vaccination of calves from 8 weeks of age with revaccination in 2 – 4 weeks (it is possible to vaccinate calves from the age of 2 weeks).


In problematic breeds, another revaccination is recommended within a period of 6 months after basic immunisation, possibly before risky period in particular breed (e.g. transfer of animals, change of the stabling system, etc.).

Pregnant cows and heifers:

Vaccination with subsequent revaccination within 7 – 5 weeks and 4 – 2 weeks before expected date of labour due to increased resistance of the offspring via colostrum.

Advice on corret administration:

Heat up the vaccine before use to a temperature of 15 to 25 °C and shake the content of the vial.
Vaccinate only healthy animals.

Withdrawal period:

Zero days.

Storage precautions:

Keep out of the reach and sight of children.Store in a refrigerator (2 °C – 8 °C)
Shelf-life of the veterinary medicinal product as packaged for sale 2 years.
Shelf-life after first opening the immediate packaging: 10 hours.

Special warning(s):

Special precautions for use in animals

Basic immunisation needs to be initiated on time, so that the protection fully developed from the beginning of the risky period of the animal.Basic immunisation of calves needs to be completed before common stabling or during quarantine.

It is recommended to vaccinate all animals in the breed, if vaccination is not contraindicated in some animals, so that the infectious burden was minimised.Failure to vaccinate each animal helps to maintain and transfer pathogens and development of the disease in the breed.

The level of antibody responses may be reduced by maternal antibodies obtained from the mothers in calves up to 6 weeks of age.

Respiratory infections in calves are often associated with bad zoohygiene.For general enhancement of zoohygiene, it is important to ensure good immunisation effect in vaccinated animals.


1 x 2 ml, 10 x 2 ml, 20 x 2 ml, 1 x 10 ml, 10 x 10 ml

1 x 20 ml, 5 x 20 ml, 10 x 20 ml, 1 x 50 ml, 1 x 100 ml

Not all pack sizes may be marketed. 

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