OESTROPHAN 0.25 mg/ml solution for injection

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Pharmaceutical form

Solution for injection.

Clear, colourless solution.

Composition

Cloprostenolum (ut natrium)                                    0.25 mg

Indication

Biotechnical

Cattle - synchronization and induction of estrus in heifers and cows;

Sows - induction of farrowing;

Mares – interruption of normal and pathological gestation (in the first half of gravidity).

Therapeutic

Functional disorders of ovaries, postpartum and post-service anestrus (in heifers: silent heat, persisting diestrus, embryo abortion, lactation anestrus, termination of pseudopregnancy), postpuerperal chronical endometritis, pyometra, interruption of either normal or pathological pregnancy in the first half of pregnancy, combined therapy of follicular cysts (starting from day 10 after HCG or LHRH treatment, after a positive ovarian response has been ascertained), induction of parturition.

Target animals

Cows, sows, mares.

Dosage and application

Method of administration:

Cattle: Intramuscularly or under mucosa using a half dose.

Sows, mares: Intramuscularly.

Synchronization of heat

Cattle: administer 2 ml of the product (500 mg of the active substance) twice, 10 days apart. The first dose of the product should be administered at any phase of the sexual cycle (in cows within a period of 40 to 60 days after calving). The second dose should be administered on day 11 after the first administration, with insemination being carried out on day 14 (72 – 76 hours after the second administration) (irrespective of manifestations of heat), and subsequent re-insemination (day 15). Any use of the product to induce synchronization in cattle must be preceded by an examination of sexual organs. Physiological condition of the sexual organs, in heifers - body and sexual maturity, are the prerequisites for the inclusion of animals into groups.

Functional disorders of ovaries

Cattle: administer 2 ml of the product; insemination is to be performed after the first heat. If the heat does not occur, the product should be administered repeatedly on day 11 after the first administration, with a subsequent insemination being performed within 72 to 76 hours, possibly with re-insemination.

Follicular cysts are treated with a single dose of 2 ml, not earlier than on day 10 after administration of HCG or LHRH, and after a positive ovarian response has been ascertained. The heat occurs on day 3 after Oestrophan administration.

Postpuerperal diseases of the uterus

Cattle: administer 2 ml of the product (if need be, the therapy may be supplemented by intra-uterine administration of foam products, and/or irrigation – best simultaneously with the administration), repeated administration follows on day 11, insemination on day 14 and re-insemination on day 15.

Pregnancy interruption

Cattle: 2 ml of the product (further treatment according to the clinical condition);

Sows: 0.7 ml pro toto (0.175 mg of the active substance) should be administered starting from day 111 of pregnancy. The majority of cases of parturition induced occur within 40 hours after the administration, namely between 24 and 35 hours.

Mares: a single dose of 1.0 ml (0.250 mg of the active substance); on cycling mares, it is administered within the period from day 5 to 13 after heat; optimal term for covering is the day 4 to 6 after administration.

Storage

Store below 25 °C.

Protect from light!

Withdrawal period

Meat – 1 day.

Milk – no withdrawal periods.

Do not use in horses the meat of which is intended for human consumption.

Shelf life

Shelf life of the veterinary medicinal product in intact package: 3 years.

Shelf life after the first opening: 28 days.

Package

10 x 2 ml, 1 x 10 ml, 10 x 10 ml, 1 x 20 ml, 5 x 20 ml, 1 x 50 ml.

Not all pack sizes may be marketed.