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EN - Anglická
  • CZ - Česká
  • SK - Slovenská
  • PL - Polská
  • RO - Rumunská
  • RU - Ruská
  • TR - Turecká
  • UA - Ukrajinská

BioBos L (6), injection suspension for cattle

Homepage Products Veterinary products BioBos L (6), injection suspension for cattle

Vaccine against leptospirosis in cattle

type of preparative: Vaccines
target species animals: Cattle

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1 dose (2 ml) contains:

Active substances:
  • Leptospira pomona inact.                                   Min. titration 16 determined by ALR*
  • Leptospira hardjo type hardjo-prajitno inact.       Min. titration 35 determined by ALR*
  • Leptospira hardjo type hardjo-bovis inact.          Min. titration 32 determined by ALR*
  • Leptospira grippotyphosa inact.                          Min. titration 64 determined by ALR*
  • Leptospira icterohaemorrhagiae inact.                Min. titration 81 determined by ALR*
  • Leptospira canicola inact.                                    Min. titration 35 determined by ALR*

 *Geometrical average of the specific antibody titres determined by agglutination-lysis  reaction (ALR) following vaccination of rabbit sera vaccinated by the batch of the vaccine that fulfilled the efficacy test by the challenge test in the target species.

Adjuvants: hydrated aluminium hydroxide 2%    7.5 mg
Excipients: thiomersal 0.2 mg, formaldehyde max. 0.19%


For active immunisation of cattle from 4 weeks of age against leptospirososis (6 serovars contained in the vaccine) to prevent infection, foetal infection and elimination of leptospires especially in urine.

Onset of immunity: 4 weeks following the basic vaccination (i.e. after administration of two initial doses)

Duration of immunity:12 months


None known.

Undesirable effects:

In rare cases of anaphylactoid reactions, symptomatic therapy is recommended.

After vaccination it is possible to expect reasonable local reactions of 5 – 20 mm in diameter, which are spontaneously absorbed during three weeks after the vaccination.

If you notice any serious undesirable effects or other reactions which are not stated in this package leaflet, please, inform your veterinarian.

Target species:


Dosage for each species, rote(s) and method of administration:

Dose – 2 ml subcutaneously behind the shoulder blade regardless of the age of the animal (calves from 4 years of age, heifers and cows).

a) Basic vaccination

Two vaccination doses are required from 4 to 6 weeks and the second dose must be administered within4 weeks before insemination. The main effects consist in prevention of elimination of leptospires in urine.

If the second vaccination dose is administered within two weeks before insemination a marked prevention of foetal infection is achieved.

The calves can be vaccinated from 4 weeks of age; the basic vaccination requires two vaccination doses.  Heifers are vaccinated once before insemination.

b) Revaccination:

To maintain protective immunity, annual revaccination of one dose within two weeks before insemination is required.

Advice on correct administration:

The vaccine must be warmed up to 15 – 25 ºC and the vial must be thoroughly shaken before use.

Withdrawal period:

No withdrawal period.

Storage precautions:

Keep out of reach of children.Store in a refrigerator (2 – 8 °C).
Protect from frost. Protect from light. Store in a dry place.
Do not use after the expiry date stated on the pack.
Shelf-life after first opening the container: 10 hours.

Special warning(s):

No information on the safety and efficacy of this vaccine is available should it be administered together with another veterinary medicinal product. Decisions on the use of this vaccine before or after any other veterinary medicinal product must be taken individually.

Do not mix with another veterinary medicinal product. It can be used during gravidity and lactation.

The effect of maternal antibodies on the efficacy of the vaccination has not been studied.

A gradual absorption of the antigen depot occurs that spontaneously disappears within 21 days following the vaccination. In the meat of animals slaughtered within 21 days following the vaccination this changed tissue must be removed, if necessary.


10 ml

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