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EN - Anglická
  • CZ - Česká
  • SK - Slovenská
  • PL - Polská
  • RO - Rumunská
  • RU - Ruská
  • TR - Turecká
  • UA - Ukrajinská

LYSVULPEN por. ad us. vet.

Homepage Products Veterinary products LYSVULPEN por. ad us. vet.

Vaccine for prophylactic vaccination of wild red foxes and racoon dogs against rabies

type of preparative: Vaccines
target species animals: Fox

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Composition - 1 dose - 1.8 ml:

Active ingredient:

Attenuated strain of the rabies virus SAD Bern composed of two dominant subpopulations of virus, namely SAD Bern and SAD B19 “like” min.1.8 x 10TCID50 – max.1.8 x 108 TCID50

Excipients:

Vaccine:
Stabilisation medium.

Bait no. 1:
Beef tallow, paraffin oil, fish meal, biomarker - tetracycline hydrochloride

Bait no. 2:
Palm oil, fish meal, hard paraffin, bergafat, biomarker - tetracycline hydrochloride

Uses:

The immunisation effect of the vaccine is based on a principle that when the animal chewes the capsule with the vaccination virus placed inside, the vaccination virus reaches the surface of mucous membranes and tonsils of the oral cavity through the capsule. Virus is in the vaccinated individual recognized as an extraneous virus, the activation of the immune system occurs, resulting in the production of protective virus-neutralisation antibodies. Immunised foxes and other target animal species are thereby protected against infection with virulent terrain rabies virus and cannot spread the rabies infection any further. Duration of immunity in vaccinated animals lasts at least for 1 year.

The protective effect against rabies may be achieved only in non-infected red foxes and racoon dogs. Also the presence of colostral antibodies against rabies has a negative effect on the onset and protective immunity in fox cubs and racoon dogs. Ingestion of several baits is harmless for the target animal species. Harmlessness of the vaccine was demonstrated in domestic animal species (dog, cat).

The vaccination rabies virus may be differentiated from a terrain rabies virus using the monoclonal antibodies.

Immunization of foxes and other target animal species occurs in case of ingestion of placed immunisation baits with the vaccination virus. The onset of immunity in vaccinated foxes and other species of target animals is 21 days after ingestion of the bait with the vaccination virus.

Indication:

For prophylactic vaccination of wild red foxes and racoon dogs against rabies.

Target animal species:

Red fox (Vulpes vulpes), racoon dog (Nyctereutes procyonoides).

Contraindication:

The vaccine must not be used for vaccination of domestic animals.

Adverse effects (frequency and severity):

Not known.

Interaction:

Not known so far.

Method of administration:

Oral.
The immunisation of target animal species occurs after consumption of placed baits with the vaccination virus. The vaccine is placed into 2 times a year, in April – May and September – October. There are usually 15 to 20 or more baits placed per km2 based on the epizootological situation and density, especially of fox population.
Distribution of baits with the vaccine must be performed uniformly in the whole area of particular territory. If a plane or a helicopter is used, it is necessary to adapt the flying lines to it. Baits are dropped e.g. each 250 m and the distance of lines from each other must also be 250 m.
If necessary, due to infectious situation in the particular area, it is recommended to perform spring and possibly autumn revaccinations, or possibly placement of baits in a limited area in the summer times or placement of baits to burrow, in a determined quantity up to 10 pcs to one burrow.

The form of bait placement from a plane is preferred on free areas and in case of low population density. Manual placement of baits is preferred in densely populated areas. Vaccination of particular area should be performed for several subsequent years, but at least for three years after the last occurrence of rabies on the particular area. It is possible to use the vaccine for the protection of area without rabies, i.e. for creation of a protective zone. The width of such zone, which reaches up to the area with rabies occurrence, should be at least 50 km.

Placement of baits from a plane
Baits are placed in accordance with prepared flying maps along predetermined flying lines. Satellite navigation system (GPS) is used for orientation and to ensure correct placement.

Dosage:

The vaccine is placed into 2 times a year, in April – May and September – October. There are usually 15 to 20 or more baits placed per km2 based on the epizootological situation and density, especially of fox population.
Distribution of baits with the vaccine must be performed uniformly in the whole area of particular territory. If a plane or a helicopter is used, it is necessary to adapt the flying lines to it. Baits are dropped e.g. each 250 m and the distance of lines from each other must also be 250 m.

Special concerns:

The vaccine must not be exposed to temperatures above 15 - 25°C (carry in thermo-suitcases, possibly packaged to thermo-isolation material, so that vaccine was sufficiently protected against the effects of higher environmental temperatures) until the time of placement, whether manual or from a plane. During manual placement in the terrain, the bait in carton box is carefully dropped on the ground. The bait is placed to the sites protected against direct sunlight and after placement, it is covered with natural material (leaves, grass, plant litter, etc.) to protect from sun.

Baits should not be placed in winter period at temperatures 0°C and lower. Frozen vaccine cannot flow out after blister perforation inside the bait and reach mucous membranes in the oral cavity and ensure vaccination of the animal. Within a period of two weeks after bait placement, free movements of dogs and cats should be prevented in the vaccination area, because they are food competitors from the point of eating the baits. The areas, where vaccination takes place, must be properly labelled and the inhabitants must be appropriately informed.

The vaccine contains an attenuated vaccination rabies virus. If the vaccine (content of aluminium-plastic blister placed in the bait) reached eyes, mouth, nose or injured skin of the human, it is necessary to seek medical advice immediately. In this case, it is proceed according to the regulations for the case of exposure to rabies virus in force. In case of hand exposure or other uncovered parts of the body with the vaccine, it is necessary to wash exposed area immediately with water and soap. Baits containing vaccine must be stored so that access of unauthorised persons, especially children, is prevented!

In case that there is a direct contact of the person's hand with the bait, it is necessary to use protective gloves during bait placement, so that the baits were not affected by human smell. Gloves are intended for single use only (for placement of 1 carton = 20 pieces of baits).

Storage:

Store and transport frozen at a temperature -20 °C or lower. Protect from light. The baits must be distributed and placed as soon as possible after defrosting. 
The preparation should not be used after the expiry date marked on the label.

Protective deadlines:

Not intended for food-producing animals.

Expiry date:

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after defrosting: max. 7 days at 25 °C.

Package:

The vaccine is filled into the aluminium-plastic blisters placed in the bait.

Package size:
a) For manual placement
Vaccine (aluminium-plastic blister with vaccine virus in the bait) is packed into cardboard box with the fixation grid with 20 pieces of baits.
Group packaging in a cardboard box is 30x20 doses (i.e. 600 doses).

b) For aerial distribution
Vaccine (aluminium-plastic blister with vaccine virus in the bait) is packed as follows:
-    by 40 doses freely in layers interleaved with tapaten in thermo-isolation cardboard box in the total amount of 400 doses
-    in polyethylene containers in amount 350, 400, 500, 600, 700, 800, 900 and 1000 doses in thermo-isolation cardboard box

Approved Package Insert is a part of every package.

 


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