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EN - Anglická
  • CZ - Česká
  • SK - Slovenská
  • PL - Polská
  • RO - Rumunská
  • RU - Ruská
  • TR - Turecká
  • UA - Ukrajinská

LYSVULPEN por. ad us. vet.

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Vaccine for prophylactic vaccination of wild red foxes and racoon dogs against rabies

type of preparative: Vaccines
target species animals: Fox

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Composition - 1 dose - 1.8 ml:

Active ingredient:

Virus rabiei attenuatum Sad Bern  MSV Bio 10 min.1.8 x 10TCID50 – max.1.8 x 108 TCID50

Excipients: stabilisation medium

In one bait there is one vaccination virus dose (1.8 ml) closed in aluminium-plastic blister.
Round, dark brown bait is made of feed mixture attractive for foxes and other target animal species.
Each bait contains 150 mg of tetracycline HCl, which is intended as an indicator of ingestion by target animal species.


An immune system is activated after a virus has penetrated into the mucosa of the oral cavity or that of nasopharynx. Immunised foxes are thus protected against an infection caused by a virulent virus and rabies distribution becomes impossible. The immunisation period is determined for a minimum of 1 year.

The vaccine contains a modified attenuated vaccinal strain MSV Bio 10 rabies, propagated in cell cultures, antibiotics and a stabilisation medium. The mixture is dispensed into blisters, plastic capsules sealed with an aluminium foil. These are covered with a bait substance including tetracycline. Tetracycline functions as a vaccination indicator. A vaccinal virus can be differentiated from a field virus if monoclonal antibodies are applied. Foxes become immunised after they have eaten laid baits containing the vaccinal virus.
In immunised foxes the immunity develops within 21 days from the day a fox has eaten the bait containing the vaccinal virus.


For prophylactic vaccination of wild red foxes and racoon dogs against rabies.

Target animal species:

Red fox (Vulpes vulpes), racoon dog (Nyctereutes procyonoides).


The vaccine must not be applied to immunise domestic animals.

Adverse effects (frequency and severity):




Method of administration:

Oral.The immunisation of target animal species takes place after consumption of placed baits with vaccination virus.The vaccine is placed 2 times a year, in April – May and September – October.There are usually 15 to 20 or more baits placed per km2 based on the epizootological situation and density, especially of fox population.Distribution of baits with the vaccine must be performed uniformly in the whole area of particular territory.If a plane or a helicopter are used, it is necessary to accommodate the flying lines to it.  Baits are dropped e.g. each 250 m and the distance of lines from each other must also be 250 m.If necessary, due to infectious situation in the particular area, it is recommended to perform spring and possibly autumn revaccinations, or possibly placement of baits in a limited area in the summer times or placement of baits to occupied earths, in a determined quantity up to 10 pcs. to one earth.  The form of bait placement from a plane is preferred on free areas and in case of low population density.In densely populated areas is preferred manual placement of baits.Vaccination of particular area should be performed for several subsequent years, but at least for three years after the last occurrence of rabies on the particular area.It is possible to use the vaccine for the protection of area without rabies, i.e. for creation of a protective zone.The width of such zone, which reaches up to the area with rabies occurrence, should be at least 50 km.

Placement of baits from a plane

Baits are placed in accordance with prepared flying maps along predetermined flying lines.Satellite navigation system (GPS) is used for orientation and to ensure correct placement.


The vaccine is laid twice a year, in April/May and in September/October, usually 15 - 20, or more units of bait per km2. The vaccines must be evenly distributed over the whole field area. If planes or helicopters are used, bait is laid every 250 m where the distance between lines is 250 m as well.

Special concerns:

The vaccine must not be exposed to temperatures above 15 °C (carriage in thermo-suitcases, possibly packaging to thermo-isolation material, so that vaccine was sufficiently protected against the effects of higher environmental temperatures) until the time of placement, whether manual or from a plane.During manual placement in the terrain is the bait in carton box carefully dropped on the ground.The bait is placed to sites protected against direct sunlight and after placement is covered with natural material (leaves, grass, plant litter, etc.) to protect from sun.

Baits should not be placed in winter period at temperatures 0 °C and lower.Frozen vaccine cannot flow out after blister perforation inside the bait and reach mucous membranes in the oral cavity and ensure vaccination of the animal.Within a period of two weeks after bait placement, free movements of dogs and cats should be prevented in the vaccination area, because they are food competitors from the point of eating the baits.Areas, where vaccination takes place, must be properly labelled and inhabitants must be appropriately informed.The vaccine contains an attenuated vaccination rabies virus.If the vaccine (content of aluminium-plastic blister placed in the bait) reached eyes, mouth or nose of a human or injured skin, it is necessary to seek medical advice immediately.In this case, it is proceeded according to the regulations for the case of exposure to rabies virus in force.In case of hand exposure or other uncovered parts of the body with the vaccine, it is necessary to wash exposed area immediately with water and soap.Baits containing vaccine must be stored so that access of unauthorised persons, especially children, was prevented!

In case that there is a direct contact of the person's hand with the bait, it is necessary to use protective gloves during bait placement, so that the baits were not affected by human smell.Gloves are intended for single use only (for placement of 1 carton = 20 pieces of baits).


The vaccine must be stored in a dark place at a temperature of -20 °C, or lower. The preparation should not be used after the expiry date marked on the label.

Protective deadlines:

Not intended for food-producing animals.

Expiry date:

24 months


For laying manually:
  • The vaccine (contents of a plastic capsule, closed with aluminium foil, stored in bait) is packed in a cardboard box with an attachment grate, each containing 20 units of bait.
  • Group packaging  - a carton containing 30x20 doses (i.e. 600 doses).
For laying by air:

The vaccine (contents of a plastic capsule, stored in bait) is packed:

  • either as 40 doses that are loosely layered with a packaging material called "tapaten" and stored in thermo-insulating cartons (group packaging is 10x40 doses in a carton), or loosely in polyethylene bags with 350 doses put into a thermo-insulating carton (group packaging - a carton containing 2x350 doses).

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